I work as an associate research scientist in computational biology at Columbia University, New York. What intrigues me is the sequence-to-structure-to-function paradigm, to understand how protein sequence determines its structure, which ultimately shapes molecular function and phenotypes.
My interest goes from microscopic to macroscopic: Can we use protein information at the atomic resolution to characterize cellular responses upon pathogen infection? I integrate molecular modeling, machine learning, enrichment and network analysis to predict pathogen host protein-protein interactions and the underlying biological pathways targeted during infection.
This systems biology approach enables us to learn principles underlying pathogen infection and identify new pharmacological targets that could potentially be used to treat a particular infection.
“All models are wrong, some are useful”
(George Box, 1919-2013)